Consequences of Stopping and Restarting Leptin in an Adolescent with Lipodystrophy
نویسندگان
چکیده
منابع مشابه
Consequences of stopping and restarting leptin in an adolescent with lipodystrophy.
BACKGROUND/AIMS Lipodystrophy encompasses a group of rare disorders characterized by deficiency of adipose tissue resulting in hypoleptinemia, and metabolic abnormalities including insulin resistance, diabetes, dyslipidemia, and nonalcoholic steatohepatitis. Leptin replacement effectively ameliorates these metabolic derangements. We report effects of leptin discontinuation and resumption in a c...
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15 صفحه اولLeptin: a novel therapeutic role in lipodystrophy.
Lipodystrophic syndromes encompass a heterogeneous group of rare disorders characterized by partial or generalized loss of adipose tissue depots (1). They are commonly associated with dyslipidemia, hepatic steatosis, and severe insulin resistance (2). The fact that insulin resistance and the consequent progression to diabetes can result from either obesity or lipodystrophy reflects the crucial ...
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ژورنال
عنوان ژورنال: Hormone Research in Paediatrics
سال: 2012
ISSN: 1663-2818,1663-2826
DOI: 10.1159/000341398